The Ford F-350 Super Duty Dually 4WD was first released to the American buying public in the F-Series line of pickup trucks for the 1948 model year. Nevertheless, the F-350 badging did not show up until the line's third generation that began in 1957. The F-350 became a top seller for consumers that required a pickup that could deal with almost any load. The impressive hauling and towing capacities made the Ford F-350 a common work truck for construction companies and farmers. Even though Ford released a Super Duty truck for the 1987 model year, the F-350 pickup didn't get the Super Duty Dually 4WD addition until 1999.

Though the Ford F-350 Super Duty Dually 4WD has been mostly used as a commercial model, many movies and TV shows have highlighted it in scenes. Movies like High Crimes, 21 Grams, and the Bruce Willis box office bestseller Live Free or Die Hard have featured the truck. Television shows that included the pickup include Law & Order: Criminal Intent starring Vincent D'Onfrio, ABC's Desperate Housewives, Comedy Central's Reno 911!, and Disney's Even Stevens.

The F-Series' 10th generation began with the F-350 Super Duty Dually 4WD. The pickup was able to handle the most demanding hauling and towing, and it included 4WD for those required the truck to be driven on rough terrain. The Super Duty is manufactured at the Blue Diamond Truck Company in Escobedo, Mexico, which concerns some buyers because of the international outsourcing. Buyers could choose from a regular cab or super cab, and also could pick from the Styleside or Flareside bed versions. The F-350 Super Duty Dually could be fitted with a variety of engine selections like a 6.8L Triton V10 to 6.0L Power Stroke turbo-diesel V8.

The 2007 model year garnered even more attention for the F-350 Super Duty Dually 4WD as it was ranked Fleet Truck of the Year in its category due mostly to the superior towing and hauling capabilities and because of its enhanced handling. Not only that, buyers also liked the fact that the model was understated and did not try to be the flashiest truck on the market.

The 2009 model year will bring some significant alterations to the Ford F-350. The exterior will receive a more modern design with defined lines, and the front end will appear more aggressive with a new grille and headlamps. Though many of the F-Series trucks are available as hybrid models, the demands of the F-350 do not make it a suitable truck to implement the present hybrid technology. Ford claims that as hybrid technology advances, the F-350 could be available as a hybrid in the future.