The 2007 Isuzu i-290 truck is available in three trim levels (S, LS, Luxury) starting from $16,989. All are equipped with a 2.8 liter, 4-cylinder engine as a manual transmission with five speeds on the S and LS and an automatic with four speeds on the Luxury. Estimated fuel consumption on a 19.6 gallon tank is 20 mpg city and 26 highway on the manual two-wheel drive and 17/24 on the automatic. Maximum payload is 1,532 lbs. with the maximum trailer weight ranging from 2,100 to 3,100 lbs. The front brakes are ventilated disc units with drums to the rear and anti-locking technology (with additional monitoring of tire pressure) is present on all wheels.

The 2007 Isuzu i-290s are equipped with a full array of air bags covering the driver and passenger with bags in the curtain position to shield against impact from the side. (There is also an automatic system for the suppression of the passenger bag's deployment.) To discourage car thieves Isuzu has provided for entry via the remote and included an alarm with an immobilizer system. The vehicle's instrumentiation includes all standard gauges including an odometer with LCD display. The standard audio unit is a radio combo on the S model while the LS adds CD and MP3 capability. The Luxury includes a changer in the dash capable of handling six discs. (Both the LS and Luxury have six speakers.)