The Isuzu i-370 is available in extended cab (2WD) or four-door Crew Cab (2WD and 4WD) models. With room for a maximum of five occupants, the truck can handle towing weights of as much as 4,000 pounds. MSRP by configuration and trim levels range from $21,078 to $25,687. (Trim levels available are the LS and the Limited.)

The standard engine for the 2007 Isuzu i-370 line is a 242 horsepower, 3.7 liter, five-cylinder with an automatic transmission with four speeds. Estimated fuel consumption on a 19.6 gallon tank is 17 mpg city and 23 highway on the 2WD models and 16/22 on the 4WD. Top payload figures range from 1,516 to 1,532 lbs. All models come standard with airbags protecting front occupants as well as bags in the curtain position to shield against impact from the side. In addition, a bag suppression system protects the front-passenger. Child seats are anchored in place with the industry standard LATCH system and door locks to the rear of the vehicle are rated as child safe. The theft protection system includes an immobilizer and the vehicle can be accessed via remote.

The standard audio system is an AM/FM/CD/MP3 system with six speakers. The Limited models add a six-disc, in-dash changer. Instrumentation includes speedometer, tachometer, fuel level, coolant temperature gauges, LCD trip odometer, and shift position indicator.