The Isuzu i-370 was launched in 2007 as a replacement for the i-350. Like the i-290, the Isuzui I-370 was a product of a joint venture between Isuzu and General Motors. The Isuzu i-370 looks a lot like other GM trucks. The Isuzu i-370 is powered by a five cylinder 3.5 liter engine. The Isuzu i-370 comes in the form of a crew cab pickup truck, which has four-wheel drive or a extended cab version which has two-wheel drive. The former is a four door vehicle while the latter is a two door vehicle. It comes in two versions only, the LS and the Limited.

The LS version of the Isuzu i-370 is equipped with airbags on the side, a system to make sure that the driver does not get locked out of the vehicle, electronic mirrors, privacy glass and support for the back of the driver and passengers. The Limited version has keyless entry, a radio system to inform the driver if the vehicle is about to be stolen, a gauge that tells the passengers what the temperature outside the vehicle is, leather steering wheel, bucket seats in the front and fog lights. The Isuzu i-370 is equipped with anti-lock brakes on all four tires and side airbags.

The interior of the Isuzu i-370 has poor interior material, though the controls to change temperatures and switch on or off the stereo are easy to find and big in size. The extended cab version has two doors in its rear, with small jump seats, which adults will find difficult to fit comfortably. The larger crew cab version has four doors, with a split-seat in the back allowing three adults to fit without a problem.