The 2007 Lexus LS 460 has a base MSRP of $61,000 with the LS 460 L starting at $71,000. Both are powered by a 380 horsepower 4.6-liter V8 with an automatic transmission with eight speeds. Fuel economy is estimated at approximately 19 mpg city and 27 highway on a 22.2 gallon tank.

Occupants enjoy the superior security of a full array of airbags including double bags in the front and those mounted in the seats to shield against forces striking from the side. Bags in the curtain position are also present and both the driver and the front passenger enjoy the added benefit of bags at the knee. Systems are in place on the vehicle for the monitoring and control of both traction and stability as well as tire pressure level. The disc brakes have power assistance. The door structure incorporates beams to absorb impact, crumple zones are present to the front and rear, and the steering column is collapsible. These features, added to the high degree of rigidity in the construction of the body, make the LS an exceptionally secure sedan.

The 2007 Lexus LS 460 offers options for navigation and parking guidance technology. Together these systems add controls activated by voice, a camera to monitor reverse motion, connectivity via Bluetooth, and XM Satellite Radio. When owners choose the premium sound option they get surround sound by Mark Levinson delivered by a 450-watt unit playing across nineteen speakers. With an included hard drive and a changer in the dash capable of holding six discs (CDs or DVDs), the media options far outstrip the competition. All of these amenities combined will add approximately $6,345 to the price of the LS.